Dept. of Chemistry

Joseph Thrasher

Joe ThrasherProfessor
Inorganic and Analytical Chemistry

Phone: (864) 656-5773
Office: 215 AMRL
E-mail: thrash5@clemson.edu

Research Interests | Publications | Patents | Books Edited

Dr. Thrasher received his B.S. (1978) and Ph.D. (1981) degrees at Virginia Tech, where he was the last doctoral student of Prof. Alan Clifford.  He was a postdoctoral research associate (1982-83) at the Freie Universität Berlin (Germany) under Prof. Konrad Seppelt before returning to the States as a Visiting Assistant Professor (1983-84) at Clemson University, where he carried out research with Prof. Darryl DesMarteau.  He then started his independent career at The University of Alabama where he rose through the academic ranks (1984-2011), including serving as Director of Graduate Studies (1995-2002) and Department Chair (2002-2007).  In the fall of 2011, Dr. Thrasher returned to Clemson University to both overlap with and then follow Prof. DesMarteau in the area of fluorine chemistry.  He was a member of the Governing Board of the Council for Chemical Research (CCR) in 2005-06.  He also served as Chair of the American Chemical Society (ACS) Division of Fluorine Chemistry (1994), co-chaired two ACS Winter Fluorine Conferences (1993 and 1995), and was lead organizer of the 19th International Symposium of Fluorine Chemistry (2009), held in Jackson Hole, WY.  He has been a guest editor of two issues of the Journal of Fluorine Chemistry.

Research Interests

Dr. Thrasher’s research involves the preparation, characterization, and utility of novel sulfur-fluorine compounds; industrial fluorine chemistry including agro- and pharmaceutical intermediates, fluoropolymer chemistry, and electrochemistry; fluorine-containing molten salts/ionic liquids; fluorous media for improved separations and catalysis; batteries and fuel cell technology; development of new analytical methodologies in fluorine chemistry; and computational chemistry.  Current projects in the Thrasher Group can be categorized into one of three different areas: (1) sulfur-fluorine chemistry, (2) industrial fluorine chemistry, and (3) fuel cell technology

Crystal Structure of (SF5)3N

Fig. 1.  Crystal Structure of (SF5)3N.

 

Percent conversion of CsC1 to CsF vs. temperature and mole ration of HF

Fig 2.  Percent conversion of CsCl to CsF vs. temperature and mole ratio of HF.                                                


Conceptual rendering of PAMAM-G0 and -G4 doped Nafion with water-sulfonic acid cluster regions.

Fig. 3. Conceptual rendering of PAMAM-G0 and -G4 doped Nafion® with water- 
           sulfonic acid cluster regions.   

                                   Fuel cell performance curves for PAMAM-G0 doped Nafion using 1 M CH3OH.          

Fig 4.  Fuel cell performance curves for PAMAM-G0 doped Nafion® using 1 M CH3OH.

                   

 Publications                                                .

Hauptfleisch JO, Hennek MD, Waterfeld A, Fernandez RE, & Thrasher JS (2012) Optimization of the photochemical generation of trifluoronitromethane, CF3NO2, and a refined purification technique. Journal of Fluorine Chemistry 133:72-76.

Husstedt, W. S.; Thrasher, J. S.; Haufe, G., Synthesis of 1-Pentafluorosulfanyl-1,3-Dienes. Synlett 2011, 2011, 1683-1686.

Howell, J. L.; Shtarov, A. B.; Thrasher, J. S.; Waterfeld, A.; Murata, K.; Friesen, C. M.; Pérez, E. W., Synthesis of New Linear Perfluoroalkyl Polyethers Starting from Diols and Tetrafluoroethylene. Lubrication Science 2011, 23, 61-80.

Sun, L. Y.; Zhu, H.; Proctor, C. A.; Felling, K. W.; Street, S. C.; O’Brien, B. A.; Thrasher, J. S. “Morphological Studies of Nafion Treated with Polyamidoamine Dendrimers,” J. Mater. Chem. 2010, submitted.

Howell, J. L.; Shtarov, A. B.; Thrasher, J. S.; Waterfeld, A.; Murata, K.; Friesen, C. M.; Pérez, E. W. “Synthesis of New Linear Perfluoroalkyl Polyethers Starting from Diols and Tetrafluoroethylene,” Lubr. Sci. 2010, in press.

Bai, L.; Zhu, H.; Thrasher, J. S.; Street, S. C. “The Synthesis and Electrocatalytic Activity of Photoreduced Platinum Nanoparticles in a Polyethylenimine Matrix,” ACS Appl. Mater. & Interfaces 2009, 1, 2304-2311.

Wan, H.; Li, S.-G.; Konovalova, T. A.; Zhou, Y.-L.; Thrasher, J. S.; Dixon, D. A.; Street, S. C. “Experimental and Theoretical Studies of the Photoreduction of Metal Ion-Dendrimer Complexes: Observations of a Delocalized Organic Radical,” J. Phys. Chem. C 2009, 113, 5358-5367.

Ol’khov, U. A.; Allayarov, S. R.; Smirnov, Yu. N.; Ol’khova, O. M.; Kispert, L. D.; Thrasher, J. S.; Dixon, D. A.; Nikles, D. E. “Effect of g-irradiation on the molecular-topological structure of the polyethylene matrix of glass-reinforced plastic,” High Energy Chem. 2007, 41(6), 430-437 (Translated from Khim. Vysokikh Energii 2007, 41(6), 488-495).

Howell, J. L.; Friesen, C. M.; Shtarov, A. B.; Thrasher, J. S.; Waterfeld, A.; Pérez, E. W.; Sullivan, J. F. “Improved thermal stability of perfluoropolyalkylethers (PFPAEs),” J. Synth. Lubr. 2007, 24, 227-234.

Holbrey, J. D.; Reichert, W. M.; Smiglak, M.; Spear, S. K.; Yang, H.; Manju, K.; Kirechenko, K.; Katrisky, A. R.; Thrasher, J. S.; Sun, L. Y.; Rogers, R. D. “Stability and Thermal Decomposition of Quaternary and Protonated Imidazolium Nitrate and Picrate Salts,” In Molten Salts XIV: Proceedings of the International Symposium; Trulove, P. C.; De long, H. C.; Mantz, R. A.; Stafford, G. R.; Matsunaga, M., Eds.; The Electrochemical Society: Pennington, NJ, 2006, 2004-24 (Molten Salts XIV), 396-406.

Sun, L. Y.; Waterfeld, A.; Thrasher, J. S. “A Modified Accelerating Rate Calorimeter (ARC®) with Capabilities for Handling Gaseous Samples under Vacuum or an Inert Atmosphere,” J. Fluorine Chem. 2006, 127, 1436-1439.

Allayarov, S. R.; Konovalova, T. A.; Waterfeld, A.; Focsan, A. L.; Jackson, V.; Craciun, R.; Kispert, L. D.; Thrasher, J. S.; Dixon, D. A. “Low-temperature fluorination of fluoro-containing polymers: EPR studies of polyvinylidenefluoride and the copolymer of tetrafluoroethylene with ethylene,” J. Fluorine Chem. 2006, 127, 1294-1301.

Dolbier, Jr., W. R.; Aït-Mohand, S.; Schertz, T. D.; Sergeeva, T. A.; Cradlebaugh, J. A.; Mitani, A.; Gard, G. L.; Winter, R. W.; Thrasher, J. S. “A convenient and efficient method for incorporation of pentafluorosulfanyl (SF5) substituents into aliphatic compounds,” J. Fluorine Chem. 2006, 127, 1302-1310.

Smiglak, M.; Reichert, W. M.; Holbrey, J. D.; Wilkes, J. S.; Sun, L. Y.; Thrasher, J. S.; Kirichenko, K.; Singh, S.; Katritzky, A. R.; Rogers, R. D. “Combustible ionic liquids by design: Is laboratory safety another ionic liquid myth?” Chem. Commun. 2006, 2554-2556.

Ol’khov, Yu. A.; Allayarov, S. R.; Chernyshova, T. E.; Barkalov, I. M.; Kispert, L. D.; Thrasher, J. S.; Fernandez, R. E.; Nikles, D. E. “Effect of g-Radiation of the Molecular-Topological Structure of Polytetrafluoroethylene,” High Energy Chem. 2006, 40(5), 310-314 (Translated from Khim. Vysokikh Energii 2006, 40(5), 355-359).

Lu, N.; Thrasher, J. S.; Ahsen, S. V.; Willner, H.; Hnyk, D.; Oberhammer, H. “Pentafluoronitrosulfane, SF5NO2,” Inorg. Chem. 2006, 45, 1783-1788.

Lu, N.; Kumar, H. P. S.; Fye, J. L.; Sun Blanks, J.; Thrasher, J. S.; Willner, H.; Oberhammer, H. “Synthesis of the Long Sought After Compound Pentafluoronitrosulfane, SF5NO2,” Angew. Chem. Int. Ed. 2006, 45, 938-940.

Allayarov, S. R.; Smirnov, Yu N.; Belov, G. P.; Kispert, L. D.; Thrasher, J. S.; Nikles, D. E. “Effect of Irradiation on the Strength Properties of Polyethylene-Matrix Glass-Reinforced Plastics,” High Energy Chem. 2005, 39, 295-298. (Translated from Khim. Vysokikh Energii 2005, 39, 343-347.)

Sun, L. Y.; Thrasher, J. S. “Studies of the thermal behavior of Nafion® membranes treated with aluminum(III),” Polym. Degrad. Stab. 2005, 89, 43-49.

Howell, J. L.; Lu, N.; Pérez, E. W.; Friesen, C. M.; Nowak, I.; Waterfeld, A. Thrasher, J. S. “The preparation of primary poly-hexafluoropropylene oxide halides (poly-HFPO-CF2X where X = I, Br, Cl and F),” J. Fluorine Chem. 2004, 125, 1513-1518.

Buschmann, J.; Lentz, D.; Luger, P.; Perpetuo, G.; Preugschat, D.; Thrasher, J. S.; Willner, H.; Wölk, H.-J. “Crystal and molecular structures of the pentafluorosulfanyl compounds, SF5X (X = -NC, -CN, -NCO, -NCS and -NCCl2) by X-ray diffraction at low temperature,” Z. Anorg. Allg. Chem. 2004, 630(7), 1136-1142.

Sipyagin, A. M.; Enshov, V. S.; Kashtanov, S. A.; Bateman, C. P.; Mullen, B. D.; Tan, Y.-T.; Thrasher, J. S. “New 4-pentafluorosulfanyl and 4-perfluoroalkylthio derivatives of 1-chloro-2-nitro- and 1-chloro-2,6-dinitrobenzenes,” J. Fluorine Chem. 2004, 125, 1305-1316.

Sipyagin, A. M.; Enshov, V. S.; Kashtanov, S. A.; Potemkin, V. A.; Thrasher, J. S.; Waterfeld, A. “Synthesis of aryl perfluoroalkyl sulfides from aromatic disulfides,” Russian Chem. Bull., Intl. Ed. (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya)2004, 53(2), 420-434.

Sipyagin, S. M.; Enshov, V. S.; Kashtanov, S. A.; Thrasher, J. S. “1-Chloro-2,6-dinitro-4-[(perfluoroalkyl)thio]benzenes in the synthesis of heterocycles,” Chem. Het. Compounds 2002, 38, 1375-1381.

Lu, N.; Thrasher, J. S. “The Direct Synthesis of Trifluoronitromethane, CF3NO2,” J. Fluorine Chem. 2002, 117, 181.

Howell, J. L.; Shtarov, A. B.; Thrasher, J. S.; Waterfeld, A.; Pérez, E. W.; Friesen, C. M; Sullivan, J. F. “Degradation of Hexafluoropropylene Oxide (HFPO) Polymers Containing Various End Groups in the Presence of Aluminum Fluoride,” in Fluoropolymer 2000:  Current Frontiers and Future Trends; Smith, Jr., D. W., Ed.; EPS, a division of eMedix, Inc.:  Hattiesburg, MS, 2001; pp 130-135.

Qiao, L.; Agoumba, D.; Thrasher, J. S. “Improvement of Polymer Electrolyte Membranes for Polymer Electrolyte and Direct Methanol Fuel Cell Applications,” in Fluoropolymer 2000:  Current Frontiers and Future Trends; Smith, Jr., D. W., Ed.; EPS, a division of eMedix, Inc.:  Hattiesburg, MS, 2001; pp 175-181.

Sipyagin, A. M.; Bateman, C. P.; Tan, Y.-T.; Thrasher, J. S. “Preparation of the first ortho-substituted pentafluorosulfanylbenzenes,” J. Fluorine Chem. 2001, 112, 287. 

Qiao, L.; Agoumba, D.; Waterfeld, A.; Thrasher, J. S “Improvement of Polymer Electrolyte Membranes for Polymer Electrolyte Membrane and Direct Methanol Fuel Cell Applications,” In Proceedings of the International Symposium on Power Sources for the New Millennium; Ryan, M. A.; Surampudi, S.; Jain, M., Eds.; Proceedings Volume 2000-22; The Electrochemical Society, Inc.:  Pennington, NJ, 2001; pp 92-102.

Sitzmann, M. E.; Gilardi, R.; Butcher, R. J.; Koppes, W. M.; Stern, A. G.; Thrasher, J. S.; Trivedi, N. J.; Yang, Z.-Y. “Pentafluorosulfanylnitramide Salts,” Inorg. Chem. 2000, 39, 843. 

Buschmann, J.; Kleinhenz, S.; Lentz, D.; Luger, P.; Madappat, K. V.; Preugschat, D.; Thrasher,, J. S. “Crystal and Molecular Structure of Trifluoroacrylnitrile, F2C=CF-CN, and Trifluorovinyl Isocyanide, F2C=CF-NC, by Low-Temperature X-ray Crystallography and Ab Initio Calculations,” Inorg. Chem. 2000, 39, 2807.

Nowak, I.; Rogers, L. M.; Rogers, R. D.; Thrasher, J. S. “The effect of fluorine on the diastereoselectivity of the addition of a-oxy radicals to 3-fluoro-2,3-dihydro-1H-l6-thiophene-1,1-dione,” J. Fluorine Chem. 1999, 99, 73-81.

“Toward the synthesis of novel fluorinated building blocks: 3,4-difluorothiophene-1,1-dioxide." Nowak, I.; Rogers, L. M.; Rogers, R. D.; Thrasher, J. S. J. Fluorine Chem. 1999, 93, 27-31.

Thrasher, J. S.; Howell, J. L. “Obituary:  Alan F. Clifford (1919-1995),” J. Fluorine Chem. 1998, 89, 1-2.

Howell, J. L.; Hofmann, M. A.; Waterfeld, A.; Sipyagin, A. M.; Friesen, C. M.; Thrasher, J. S. “Reactions of Poly-Hexafluoropropylene Oxide Acids and Their Corresponding Salts,” J. Fluorine Chem. 1998, 89, 131.

Howell, J. L.; Hofmann, M. A.; Waterfeld, A.; Sipyagin, A. M.; Friesen, C. M.; Thrasher, J. S. “Reactions of Perfluoropolyether (PFPE) Acids and Their Corresponding Salts,” Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 1998, 39(2), 822.

Liu, T.-L.; Thrasher, J. S.; Lake, B. K.; Qiao, L.; Waterfeld, A. “Applications of Microscopy to the Study of Electrochemical Fluorination,” In Proceedings of the Symposium on Electrochemistry in the Preparation of Fluorine and Its Compounds, Childs, V. W.; Fuchigami, T.; Eds.; Proceedings Volume 97-15; The Electrochemical Society, Inc.:  Pennington, NJ, 1997; p 220.

Preugschat, D.; Thrasher, J. S. “Pentacarbonyl Chromium Complexes of SF5-substituted Isocyanides,” Z. Anorg. Allg. Chem. 1996, 622, 1411.

Sun, J.; Thrasher, J. S. “Experimental and Theoretical Research Towards RfNCl3+ Cations, where Rf = CF3, SF5, FC(O), and F,” J. Fluorine Chem. 1995, 71, 213.

Fernandez, R. E.; Thrasher, J. S. “Alkali Metal Polyhydrogen Fluorides: Useful Halogen-Exchange Media,” In Inorganic Fluorine Chemistry:  Toward the 21st Century; Thrasher, J. S.; Strauss, S. H., Eds.; ACS Symposium Series 555; American Chemical Society:  Washington, DC, 1994; pp 237-250.

Thrasher, J. S. ; Strauss, S. H. “Inorganic Fluorine Chemistry:  Toward the 21st Century,”In Inorganic Fluorine Chemistry:  Toward the 21st Century; Thrasher, J. S.; Strauss, S. H., Eds.; ACS Symposium Series 555; American Chemical Society:  Washington, DC, 1994; pp 1-23.

Thrasher, J. S.; Timkovich, R.; Kumar,  H. P. S.; Hathcock, S. L. “Moisture Solubility in R-123 and R-134A,” ASHRAE Trans. 1994, 100, 346.

St. Clair, A. K.; St. Clair, T. L.; Thrasher, J. S. “Polyimides Containing Pentafluorosulfanylbenzene,” Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 1993, 34, 385.

Jesih, A.; Sipyagin, A. M.; Chen, L.-F.; Hong, W.-D.; Thrasher, J. S. “Preparation of 1,3-Diamino-5-pentafluorosulfanylbenzene:  A New Monomer for Polymer Synthesis,” Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 1993, 34, 383.

Madappat, K. V.; Clark, M.; Thrasher, J. S. “A Computational Study of the Possible Isomers and Conformations of N-Trifluoromethylformamide, CF3NHC(O)H, and N-Hydroxymethylidene-trifluoromethylamine, CF3N=C(H)OH,” J. Mol. Struct. (Theochem) 1993, 285, 1.

Patents

“Thermally stable perfluoropolyethers and processes thereof and therewith,” J. L. Howell, E. W. Pérez, A. Waterfeld, C. M. Friesen, J. S. Thrasher, U.S. Patent 7,232,932, June 19, 2007.

“Perfluoropolyether primary bromides and iodides,” J. L. Howell, E. W. Pérez, A. Waterfeld, C. M. Friesen, J. S. Thrasher, and I. Nowak, U.S. Patent 7,148,385, December 12, 2006.

“Perfluoropolyethers and processes therefor and therewith,” J. L. Howell, E. W. Pérez, A. Waterfeld, C. M. Friesen, J. S. Thrasher, EP1632516, March 8, 2006.

“Thermally stable perfluoropolyethers and processes thereof and therewith,” J. L. Howell, E. W. Pérez, A. Waterfeld, C. M. Friesen, J. S. Thrasher, U.S. Patent 6,753,301, June 22, 2004.

“Perfluoropolyether primary bromides and iodides,” J. L. Howell, E. W. Pérez, A. Waterfeld, C. M. Friesen, J. S. Thrasher, and I. Nowak, U.S. Patent 6,653,511, November 25, 2003.

“Perfluoropolyethers and processes therefor and therewith,” J. L. Howell, E. W. Pérez, A. Waterfeld, C. M. Friesen, J. S. Thrasher, WO0206375, January 24, 2002. 

Cicha, W. V.; Kornath, A. J.; McKinney, R. J.; Rao, V. N. M.; Thrasher, J. S.; Waterfeld, A. “Perfluoroalkanesulfonates, their preparation and use as catalysts for increasing fluorine content of halogenated hydrocarbons and as promoter for hydrocyanation of olefins,” U.S. Patent 5,773,637, June 30, 1998.

St. Clair, T. L.; St. Clair, A. K.; Thrasher, J. S. “1,3-Diamino-5-pentafluorosulfanylbenzene,” U.S. Patent 5,220,070, 1993.

Books Edited
Inorganic Fluorine Chemistry:  Toward the 21st Century; Thrasher, J. S.; Strauss, S. H., Eds.; ACS Symposium Series 555; American Chemical Society:  Washington, DC, 1994.

 

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