R. Kenneth Marcus
Professor
Analytical Chemistry
Phone: (864) 656-5011
Office: 106 Biosystems Research Complex
E-mail: marcusr@clemson.edu
Research Interests | Publications | Research Group
Dr. Marcus earned B.S. degrees (1982) in chemistry and physics from Longwood College and a Ph.D. (1986) in analytical chemistry from the University of Virginia. He serves on the editorial advisory board for four international journals and was the recipient of the 2001 S.C. Governor¹s Award for Excellence in Science Research.
Research Interests
The development and application of new plasma techniques for the atomic spectroscopic analysis of diverse materials is a major focus of this research group. Included in this work is the design of atomic emission and mass spectrometry instrumentation employing glow discharge (GD) sources. Plasma sources have been developed for the analysis of electronic grade materials, polymers and a variety of layered systems. Instrumentation developed in the Marcus laboratory is now commercially available from a number of manufacturers.
A continuing area of emphasis has been the development of novel detection methods for liquid chromatography. Low-pressure plasma sources provide unambiguous molecular and elemental analysis information, which is vital for biological systems regarding the essential and toxic character of different metal species. A recent development has been the use of a low lower atmospheric pressure plasma for the sampling of capillary separations. This plasma offers excellent absolute sensitivities on a platform that is readily employed with lab-on-a-chip experiments. The most recent area of liquid chromatography development is a new class of channeled-polymer fibers as stationary phases, providing very efficient solution flow along with high surface areas.
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Publications
R. Kenneth Marcus, “Use of Polymer Fiber Stationary Phases for Liquid Chromatography Separations: Part I - Physical and Chemical Rationale”, J. Sep. Sci. 31,1923-1935, 2008.
M. V. Balarama Krishna and R. Kenneth Marcus, Role of Cathode Identity in Liquid Chromatography Particle Beam Glow Discharge Mass Spectrometry (LC-PB/GDMS)", Spectrochimica Acta, Part B, 63, 673-684, 2008.
Joaudimir Castro, M. V. Balarama Krishna, and R. Kenneth Marcus, “Liquid Chromatography-Particle Beam/Mass Spectrometry Analysis of Botanical Products Using Both Electron Impact and Glow Discharge Ionization Sources”, Am. Lab. News 40 (4), 8-10, 2008.
Jacob L. Venzie, Joaudimir Castro, M. V. Balarama Krishna, Dwella M. Nelson and R. Kenneth Marcus, “Electron Impact and Glow Discharge Ionization LC/MS Analysis of Green Tea Tincture”, Anal. Bioanal. Chem. 387, 321-333, 2007.
M. V. Balarama Krishna, Joaudimir Castro, Tim M. Brewer, and R. Kenneth Marcus, “Online Mercury Speciation Through Liquid Chromatography with Particle Beam/Electron Ionization Mass Spectrometry Detection”, J. Anal. Atom. Spectrom.,22, 283-291, 2007.
Rayman D. Stanelle, Christine M. Straut, and R. Kenneth Marcus, “Nylon-6 Capillary-Channeled Polymer Fibers as a Stationary Phase for the Mixed-Mode Ion Exchange/Reversed-Phase Chromatography Separation of Proteins”, J. Chromatogr. Sci., 45, 415-421, 2007.
Tim M. Brewer and R. Kenneth Marcus, “Separation and Determination of Fe-Containing Proteins via Liquid Chromatography-Particle Beam/Hollow Cathode-Optical Emission Spectroscopy (LC-PB/HC-OES)”, Anal. Chem. 79, 2402-2411, 2007.
Joaudimir Castro and R. Kenneth Marcus, “Analysis and Characterization of Botancial Products: Speciation by Particle Beam Glow Discharge Mass Spectrometry”, G.I.T. Lab. J. 3-4, 58-59, 2007.
Tim M. Brewer and R. Kenneth Marcus, “Determination of “Free” Iron and Iron Bound in Metalloproteins via Liquid Chromatography Separation and Inductively Coupled Plasma-Optical Emission Spectroscopy (LC-ICP-OES) and Particle Beam/Hollow Cathode-Optical Emission Spectroscopy (LC-PB/HC-OES) Techniques)", J. Anal. At. Spectrom. 22, 1067-1075, 2007.
Dwella M. Nelson and R. Kenneth Marcus, “Potential for Ultrafast Protein Separations with Capillary-Channeled Polymer (C-CP) Fiber Columns”, Protein Peptide Letts., 13, 95-99, 2006.
Rayman D. Stanelle, Massimiliano Mignanelli, Phil Brown, and R. Kenneth Marcus, “Capillary-Channeled Polymer (C-CP) Fibers as a Stationary Phase in Microbore High-Performance Liquid Chromatography Columns”, Anal. Bioanal. Chem. 384, 250-258, 2006.
Jacob L. Venzie and R. Kenneth Marcus, “Effects of Easily Ionizable Elements on the Liquid Sampling-Atmospheric Pressure Glow Discharge”, Spectrochim. Acta B, 61, 715-721,2006.
Tim M. Brewer, Joaudimir Castro and R. Kenneth Marcus, “Particle Beam Sample Introduction into Glow Discharge Plasmas for Speciation Analysis”, Spectrochim. Acta Part B, 61, 134-149, 2006.
Tim M. Brewer and R. Kenneth Marcus, “Plasma Parameter and Film Casting Optimization for the Determination of Particulate Matter in a Sol-gel Matrix by Radio Frequency Glow Discharge Optical Emission Spectroscopy (rf-GD-OES)”, J. Anal. At. Spectrom., 21, 126–133, 2006.
D. Seth Fornea, Yonnie Wu, and R. Kenneth Marcus, "Capillary Channeled Polymer Fibers as a Stationary Phase for Desalting of Protein Solutions for Electrospray Ionization Mass Spectrometry Analysis", Anal. Chem., 78, 5617-5621, 2006.
Tim M. Brewer and R. Kenneth Marcus, “Determinations of Sol-Gel Immobilized Nucleotides Through Non-Metal Element Detection by Radio Frequency Glow Discharge Optical Emission Spectrometry (rf-GD-OES)”, Anal. Bioanal. Chem. 386, 1357-1365, 2006.
Dwella M. Nelson and R. Kenneth Marcus, “Protein Separations by Reversed-Phase Liquid Chromatography Employing Capillary-Channeled Polymer (C-CP) Fibers as Stationary Phases: Comparative Analysis with a Packed-Bed Column”, Anal. Chem. 78, 8462-8471, 2006.
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